Transcriptional Control of B-Cell Differentiation by EBF and E2A

摘要: B-cell differentiation is a complex developmental process that ultimately generates antibody-secreting plasma cells. The lineage involves multiple stages of have been characterized by the expression cell surface markers and rearrangement status immunoglobulin (Ig) loci (Fig. 1). earliest cells are committed to express B220, CD43, AA4.1 Ig heavy chain locus in germline configuration (1, 2). Pro-B preB-cells genes involved gene signal transduction through pre-B-cell receptor (reviewed 3,4). In particular, these recombinase-activating (Rag1 Rag2), terminal deoxytransferase (TdT), λ5 VpreB encoding surrogate light chains, mb-1 B29 Igα Igβ proteins mediate signaling. pro-B- pre-B-cells can be subdivided into populations different combinations may represent distinct 1) (1,5). Further immature B-cells rearranged their downregulated ref. 6). Taken together, early antigen-independent phase occurs predominantly adult bone marrow. late occur peripheral lymphoid organs involve activation antigen and/or T helper generation These also result somatic hypermutation antibody class switching 7).