A second-generation genetic linkage map of the domestic dog, Canis familiaris.

摘要: Purebred strains, pronounced phenotypic variation, and a high incidence of heritable disease make the domestic dog uniquely suited to complement genetic analyses in humans mice. A comprehensive linkage map would afford many opportunities dogs, ranging from positional cloning genes dissection quantitative differences size, shape, behavior. Here we report canine with number mapped loci expanded 276 10-cM coverage extended 75-90% genome. Most 38 autosomes are likely represented collection 39 autosomal groups. Eight markers were sufficiently informative detect at distances 10-13 cM, yet remained unlinked any other marker. Taken together, results suggested genome size about 27 M. As species, length varied between sexes, female distance being approximately 1.4-fold greater than that male meioses. Fifteen anchored well-described on map, thereby serving as landmarks for comparative mapping dogs. We discuss utility current outline steps necessary future improvement.