d-cycloserine improves sociability and spontaneous stereotypic behaviors in 4-week old mice

摘要: Abstract Balb/c mice are a model of impaired sociability and social motivation relevant to autism spectrum disorders (ASDs). Impaired 8-week old is attenuated by agonists the glycineB site on NMDA receptor, such as d -cycloserine. Although ASDs often recognized in toddlerhood, there interest earlier identification (e.g., before 6 months) disease-modifying interventions improve functional outcomes. Thus, we wondered if -cycloserine could 4-week mice, similar its effects mice. -Cycloserine improved measures (i.e., one-week post-weanling) Moreover, because stereotypies can compete with salience stimuli, compared Swiss Webster several spontaneous stereotypic behaviors emerging during interaction stimulus mouse. Interestingly, were more intense mice; furthermore, reduced their intensity. improves both behaviors, but these may lack strain-selectivity. A prosocial effect was observed at dose low 32.0 mg/kg has therapeutic properties desired medication for ASDs; specifically, should not expense worsening vice versa. The data suggest that targeting receptor have promising two prominent domains psychopathology ASDs: behaviors.