HMGB1 promotes hair growth via the modulation of prostaglandin metabolism
作者： Ji-Hye Hwang , Howard Chu , Yuri Ahn , Jino Kim , Do-Young Kim
DOI: 10.1038/S41598-019-43242-2
关键词:
摘要: Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but likely related to inflammatory mediators. One such mediator high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that released from cell nuclei damage. To elucidate the effect of HMGB1 on and understand its action, we evaluated treatment shaft elongation mRNA expression in cultured human dermal papilla cells (hDPCs). enhanced an ex vivo organ culture. In hDPCs, significantly increased levels prostagladin E synthases. also stimulated prostaglandin E2 (PGE2) secretion hDPCs. Finally, blocking receptor advanced glycation end-products, canonical receptor, inhibited HMGB1-induced PGE2 production elongation. Our results suggest promotes via This explain paradoxical trauma-induced growth. Thus, HGMB1 be viable therapeutic target alopecia.
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sci-hub.se 参考文章(43)
Angelika Bierhaus, Peter P Nawroth, David M Stern, RAGE in inflammation: a new therapeutic target? Current opinion in investigational drugs. ,vol. 7, pp. 985- 991 ,(2006)
Anita L. Sabichi, Norma Llansa, Vemparala Subbarayan, Scott M. Lippman, David G. Menter, Differential Expression of Cyclooxygenase-2 and Its Regulation by Tumor Necrosis Factor-α in Normal and Malignant Prostate Cells Cancer Research. ,vol. 61, pp. 2720- 2726 ,(2001)
Sven Müller-Röver, Kerstin Foitzik, Ralf Paus, Bori Handjiski, Carina van der Veen, Stefan Eichmüller, Ian A. McKay, Kurt S. Stenn, A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. Journal of Investigative Dermatology. ,vol. 117, pp. 3- 15 ,(2001) , 10.1046/J.0022-202X.2001.01377.X
W.R. Hanson, A.E. Pelka, A.K. Nelson, F.D. Malkinson, Subcutaneous or topical administration of 16,16 dimethyl prostaglandin E2 protects from radiation-induced alopecia in mice☆ International Journal of Radiation Oncology Biology Physics. ,vol. 23, pp. 333- 337 ,(1992) , 10.1016/0360-3016(92)90750-C
Henry H. Roenigk, New topical agents for hair growth Clinics in Dermatology. ,vol. 6, pp. 119- 121 ,(1988) , 10.1016/0738-081X(88)90075-2
Stefania Straino, Anna Di Carlo, Antonella Mangoni, Roberta De Mori, Liliana Guerra, Riccardo Maurelli, Laura Panacchia, Fabio Di Giacomo, Roberta Palumbo, Cristiana Di Campli, Luigi Uccioli, Paolo Biglioli, Marco E. Bianchi, Maurizio C. Capogrossi, Antonia Germani, High-mobility group box 1 protein in human and murine skin: involvement in wound healing. Journal of Investigative Dermatology. ,vol. 128, pp. 1545- 1553 ,(2008) , 10.1038/SJ.JID.5701212
M.R. Namazi, UV light may induce hypertrichosis through production of PGE2 Medical Hypotheses. ,vol. 68, pp. 917- 918 ,(2007) , 10.1016/J.MEHY.2006.08.028
Amandine Jaulmes, Sylvain Thierry, Brigitte Janvier, Michel Raymondjean, Vincent Maréchal, Amandine Jaulmes, Sylvain Thierry, Brigitte Janvier, Michel Raymondjean, Vincent Maréchal, Activation of sPLA2-IIA and PGE2 production by high mobility group protein B1 in vascular smooth muscle cells sensitized by IL-1β The FASEB Journal. ,vol. 20, pp. 1727- 1729 ,(2006) , 10.1096/FJ.05-5514FJE
P. Leclerc, H. Wähämaa, H. Idborg, P. J. Jakobsson, H. E. Harris, M. Korotkova, IL-1β/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts. Scandinavian Journal of Immunology. ,vol. 77, pp. 350- 360 ,(2013) , 10.1111/SJI.12041
Paola Scaffidi, Tom Misteli, Marco E. Bianchi, Release of chromatin protein HMGB1 by necrotic cells triggers inflammation Nature. ,vol. 418, pp. 191- 195 ,(2002) , 10.1038/NATURE00858