Granulocyte–macropha ge colony‐stimulating factor down‐regulates CD14 expression on monocytes

摘要: CD14 is a differentiation-stage-linked glycosyl-phophatidyl-inositol-linked glycoprotein on human peripheral blood monocytes and tissue macrophages, which functions as receptor for lipopolysaccharide. Here, the effects of granulocyte–macrophage colony-stimulating factor (GM-CSF), cytokine with proliferation- differentiation-inducing properties myeloid lineage cells, were studied expression by cells. GM-CSF down-regulated membrane monocytes, while it up-regulated neutrophils. also decreased spontaneous release in monocyte culture supernatants. Down-regulation was accompanied decrease mRNA transcript CD14, suggesting that most likely reflects an effect transcriptional level. The functional significance this phenomenon, its potential relation to terminal differentiation are discussed.