Electrolyte disorders associated with the use of anticancer drugs.

摘要: The use of anticancer drugs is beneficial for patients with malignancies but frequently associated the occurrence electrolyte disorders, which can be hazardous and in many cases fatal. review presents abnormalities that occur provides related mechanisms. Platinum-containing induce hypomagnesemia, hypokalemia hypocalcemia. Moreover, platinum-containing are hyponatremia, especially when combined large volumes hypotonic fluids aiming to prevent nephrotoxicity. Alkylating agents have been linked hyponatremia [due syndrome inappropriate antidiuretic hormone secretion (SIADH)] Fanconi's (hypophosphatemia, aminoaciduria, hypouricemia and/or glucosuria). Vinca alkaloids due SIADH. Epidermal growth factor receptor monoclonal antibody inhibitors Other, antibodies, such as cixutumumab, cause Tyrosine kinase hypophosphatemia. Mammalian target rapamycin (due aldosterone resistance), Other immunomodulators or methotrexate also hyponatremia. administration estrogens at high doses, streptozocin, azacitidine suramin may Finally, drug-related tumor lysis hyperphosphatemia, hyperkalemia prevention derangements lead reduction adverse events during drugs.