The Cognitive Consequences of Structural Changes to the Aging Brain

摘要: Publisher Summary This chapter reviews the history of morphometric research on normal brain aging and examines in detail, recently developed techniques for measuring brain's structure exploring structure- function association studies conducted within each neuroimaging modality context aging. For comparison purposes, it with participants showing “normal” aging, a methodology technique following most standard protocols. Because state affects quality its function, study changes has proven fruitful understanding cognitive Brain's ostensibly relies structural integrity. Therefore, many have embarked relating age differences regional volume to their putative underlying function. The resulting literature is mixed findings because fluctuates over decades (incorporating growth shrinkage), middle older aged adults are probably able compensate degradation time or rely upon reserve resources declines Further, structure-cognition associations not easily replicated sensitive type assessment sample composition. In this context, summarizes cognition by domain. It concludes look toward needed future directions particular focus combined multimodality structure–function more careful selection characterization health indices selected studies.