Recent advances in characterization of nonviral vectors for delivery of nucleic acids: impact on their biological performance
作者： Claudia Oliveira , Isabel Silveira , Francisco Veiga , António J Ribeiro
DOI: 10.1517/17425247.2014.945421
关键词:
摘要: Introduction: Nucleic acid delivery is a complex process that requires transport across numerous extracellular and intracellular barriers, whose impact often neglected during optimization studies. As such, the development of nonviral vectors for efficient would benefit from an understanding how these barriers relate to physicochemical properties lipoplexes polyplexes.Areas covered: This review focuses on evaluation parameters associated with such as blood immune cells compatibility which, collective, may serve useful prescreening tool advancement in vivo. An outline most relevant rationally developed polyplexes clinical application also given.Expert opinion: The scientifically recognized enabled identification systemic delivered vectors’ behavior while one key determinants function activity both vitro ...
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