Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway.

作者: Kalina Andreeva , Sheng Gao , Nigel G. F. Cooper

DOI:

关键词:

摘要: Purpose Ischemia-reperfusion (IR) injury is involved in the pathology of many retinal disorders since it contributes to death neurons and subsequent decline vision. We determined molecular patterns some principal molecules necroptosis investigated whether IR associated with extracellular signal-regulated kinase-1/2- receptor-interacting protein kinase 3 (ERK1/2-RIP3) pathway.

参考文章(56)
JingJing Gong, Saikartik A. Kumar, Gilian Graham, Addanki P. Kumar, FLIP: Molecular switch between apoptosis and necroptosis Molecular Carcinogenesis. ,vol. 53, pp. 675- 685 ,(2014) , 10.1002/MC.22027
Malin Malmsjö, Bodil Gesslein, Gisela Håkansson, Maria Thereza Perez, Ronald Carpio, Lotta Gustafsson, Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. Molecular Vision. ,vol. 16, pp. 392- 407 ,(2010)
Hongliang Zong, Angelina Madden, Micheal Ward, Mark H Mooney, Christopher T Elliott, Alan W Stitt, None, Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction. Journal of Biological Chemistry. ,vol. 285, pp. 23137- 23146 ,(2010) , 10.1074/JBC.M110.133827
Javier Sancho-Pelluz, Blanca Arango-Gonzalez, Stefan Kustermann, Francisco Javier Romero, Theo van Veen, Eberhart Zrenner, Per Ekström, François Paquet-Durand, Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration Molecular Neurobiology. ,vol. 38, pp. 253- 269 ,(2008) , 10.1007/S12035-008-8045-9
Katsuya Ishihara, Kae Tsutsumi, Shiho Kawane, Motowo Nakajima, Tatsuhiko Kasaoka, The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site FEBS Letters. ,vol. 550, pp. 107- 113 ,(2003) , 10.1016/S0014-5793(03)00846-9
Agnieszka Kaczmarek, Peter Vandenabeele, Dmitri V. Krysko, Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance Immunity. ,vol. 38, pp. 209- 223 ,(2013) , 10.1016/J.IMMUNI.2013.02.003
E. Bonfoco, D. Krainc, M. Ankarcrona, P. Nicotera, S. A. Lipton, Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 7162- 7166 ,(1995) , 10.1073/PNAS.92.16.7162
R Fujita, M Ueda, K Fujiwara, H Ueda, Prothymosin- α plays a defensive role in retinal ischemia through necrosis and apoptosis inhibition Cell Death & Differentiation. ,vol. 16, pp. 349- 358 ,(2009) , 10.1038/CDD.2008.159