Method of prevention and treatment of aging, age-related disorders and/or age-related manifestations including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimer's disease and cancer

摘要: This invention relates to a method for prevention and treatment of aging, age-related disorders and/or manifestations including atherosclerosis, peripheral vascular disease, coronary artery osteoporosis, type 2 diabetes, dementia some forms arthritis cancer in subject comprising administering said subject, separately, sequentially or simultaneously therapeutically effective dosage each component combination statins, bisphosphonates, cholesterol lowering agents techniques, interleukin-6 inhibitor/antibody, receptor antisense oligonucleotide (ASON), gp130 protein tyrosine kinases inhibitors/antibodies, serine/threonine mitogen-activated (MAP) kinase phosphatidylinositol 3-kinase (PI3K) Nuclear factor κB (NF-κB) IκB (IKK) activator protein-1 (AP-1) STAT transcription factors altered IL-6, partial peptides IL-6 receptor, SOCS (suppressors cytokine signaling) protein, functional fragment thereof, administered sequence simultaneously. Inhibition the signal transduction pathway Interleukin 6 mediated inflammation is key tumors. may be achieved indirectly through regulation endogenous synthesis isoprenoid depletion by direct inhibition utilizing thereof. Said based on Interleukin-6 metabolism,