Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease.

摘要: We established that follicular dendritic cells (FDCs) are the site of abnormal prion protein (PrPCJD) accumulations in lymphoid tissues from mice infected with Creutzfeldt-Jakob disease. Evidence positive FDC staining was observed disease-infected irrespective inoculation route, while no such seen control mice. also found severe combined immunodeficiency mouse trait is transmittable via intracranial route but not intraperitoneal route. Mice did have PrPCJD accumulation FDCs.