A case-control study of amyotrophic lateral sclerosis.

摘要: The authors conducted a study of 518 amyotrophic lateral sclerosis patients identified between 1977 and 1979 controls to investigate putative risk factors for this disease. Occupations at electrical exposure were reported more often by (odds ratio (OR) = 3.8, 95% confidence interval (CI) 1.4-13.0) as shocks producing unconsciousness (OR 2.8, CI 1.0-9.9). Although an overall excess physical trauma associated with was observed in the 1.6, 1.0-2.4), effect inversely duration unconscious episodes, suggesting recall bias. Only slight differences found surgical traumata nervous system. Parkinsonism among first degree relatives cases 2.7, 1.1-7.6). frequencies prior poliomyelitis or other central system diseases similar controls. Occupational selected toxic substances except manufacture plastics 3.7, 1.0-20.5), although few details these exposures provided. No occupations animal skins hides observed.