EFFECT OF INDOMETHACIN ON GASTRIC MUCOSAL BLOOD FLOW AROUND ACETIC ACID-INDUCED GASTRIC ULCERS IN RATS

摘要: Repeated administration of indomethacin markedly delays spontaneous healing experimental gastric ulcers induced in rats. To elucidate the underlying mechanism, effect on mucosal blood flow around was examined. Gastric were 5 days after submucosal injection an acetic acid solution into stomachs Blood determined by hydrogen gas clearance method. The significantly higher than that rats without up to 2 weeks ulceration but had returned within normal range 3 or 4 later. Indomethacin, administered SC at 1 mg/kg once repeatedly for 1–4 weeks, little no However, such treatment reduced 20%–30% corresponding control levels with ulcers. Prostaglandin E2, once, prevented reduction due indomethacin. prostaglandin resulted a blood-flow level and delay ulcer healing. Omeprazole, 30 insignificant In conclusion, delayed caused might be partly related