Interactions between glomerular mesangial cells, cytokines, and extracellular matrix.

摘要: This brief overview summarizes recent information on the interactions of glomerular mesangial cells (MC) with soluble cytokines and nonsoluble extracellular matrix (ECM). The presently available knowledge stems largely from cell culture studies experimental work laboratory animals. ECM production by MC appears to be regulated primarily paracrine or autocrine effects cytokines, such as interleukin 1, platelet-derived growth factor, transforming factor beta. However, itself also affects behavior cultured MC, e.g., regard replication components other proteins. At present, little is known about recognition that allows these take place. First results indicate like types, possess surface proteins belonging beta 1 integrin family, which serve specific receptors for molecules. Receptors insulin-like epidermal have been demonstrated MC. expression various affected substratum. Thus, it becoming apparent not only important a mechanical scaffold capillary tuft but contains conveys relevant regulation phenotype, modulating response cytokines. evidence suggests alterations composition in disease can directly indirectly affect behavior, promoting further accumulation ECM, eventually resulting progressive sclerosis.