Synthesis of tools for target identification of the anti-apoptotic compound CGP 3466; Part I.

作者: Kaspar Zimmermann , Silvio Roggo , Eddy Kragten , Peter Fürst , Peter Waldmeier

DOI: 10.1016/S0960-894X(98)00188-7

关键词:

摘要: Immobilized compounds for BIAcore studies and affinity precipitation as well a fluorescent-labeled compound were prepared in order to identify the molecular target of anti-apoptotic, neurorescuing CGP 3466 (N-methyl-N-propargyl-10-aminomethyl-dibenzo[b,f]oxepin).

参考文章(11)
William G. Tatton, K. Ansari, W. Ju, P. T. Salo, Peter H. Yu, Selegiline induces "trophic-like" rescue of dying neurons without MAO inhibition. Advances in Experimental Medicine and Biology. ,vol. 363, pp. 15- 16 ,(1995) , 10.1007/978-1-4615-1857-0_2
Eleni Koutsilieri, Tzyh-Shi Chen, Wolf-Dieter Rausch, Peter Riederer, None, Selegiline is neuroprotective in primary brain cultures treated with 1-methyl-4-phenylpyridinium. European Journal of Pharmacology. ,vol. 306, pp. 181- 186 ,(1996) , 10.1016/0014-2999(96)00184-7
Catherine Mytilineou, Gerald Cohen, Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion. Journal of Neurochemistry. ,vol. 45, pp. 1951- 1953 ,(1985) , 10.1111/J.1471-4159.1985.TB10556.X
Catherine Mytilineou, Pheona Radcliffe, Efthimia Kokotos Leonardi, Peter Werner, C. Warren Olanow, l-Deprenyl Protects Mesencephalic Dopamine Neurons from Glutamate Receptor-Mediated Toxicity In Vitro Journal of Neurochemistry. ,vol. 68, pp. 33- 39 ,(2002) , 10.1046/J.1471-4159.1997.68010033.X
P. T. Salo, W. G. Tatton, Deprenyl reduces the death of motoneurons caused by axotomy. Journal of Neuroscience Research. ,vol. 31, pp. 394- 400 ,(1992) , 10.1002/JNR.490310223
I.A PATERSON, A.J BARBER, D.L GELOWITZ, C VOLL, Deprenyl Reduces Delayed Neuronal Death of Hippocampal Pyramidal Cells Neuroscience & Biobehavioral Reviews. ,vol. 21, pp. 181- 186 ,(1997) , 10.1016/S0149-7634(96)00008-5
W. G. Tatton, W. Y. L. Ju, D. P. Holland, C. Tai, M. Kwan, (−)-Deprenyl Reduces PC12 Cell Apoptosis by Inducing New Protein Synthesis Journal of Neurochemistry. ,vol. 63, pp. 1572- 1575 ,(2002) , 10.1046/J.1471-4159.1994.63041572.X
Eddy Kragten, Isabelle Lalande, Kaspar Zimmermann, Silvio Roggo, Patrick Schindler, Dieter Müller, Jan van Oostrum, Peter Waldmeier, Peter Fürst, Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl. Journal of Biological Chemistry. ,vol. 273, pp. 5821- 5828 ,(1998) , 10.1074/JBC.273.10.5821
W. G. Tatton, C. E. Greenwood, Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism. Journal of Neuroscience Research. ,vol. 30, pp. 666- 672 ,(1991) , 10.1002/JNR.490300410
D M Chuang, K Sunaga, N Katsube, R Ishitani, M Kimura, M Tanaka, An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebrocortical neurons in culture. Journal of Pharmacology and Experimental Therapeutics. ,vol. 278, pp. 447- 454 ,(1996)