Hypertrophic Growth of Vascular Smooth Muscle

摘要: Smooth muscle cell (SMC) growth is increased in arteries of hypertensive patients and animals [1,12,24,30,36]. This contributes to development medial thickening resistance vessels [1,10] has been hypothesized play an important role the etiology hypertension by conferring a geometric advantage thickened vessel such that vascular greater at any given level smooth activation [9]. In contrast, large conduit vessels, accelerated believed represent adaptive process minimize changes wall stress resulting from blood pressure [27,28]. Whereas arterial cells common feature virtually all models, cellular nature response, with regard contribution hypertrophy versus hyperplasia, appears vary as function site examined and/or model studied [29]. For example, aortic spontaneously rat (SHR) due primarily enlargement preexisting SMCs or hypertrophy, accompanied polyploidy fraction hypertrophic [29,32,33]. intermediate-size SHR aorta rats made coarctation SMC hyperplasia [31].