The effect of prescription opioid injection on the risk of non-fatal overdose among people who inject drugs.

摘要: Abstract Objectives Prescription opioid (PO) use by people who inject drugs (PWID) is a growing public health concern. Non-fatal overdose remains leading source of morbidity among PWID, however, little known about the relationship between PO injection and non-fatal in this population. In study we sought to examine impact on PWID from Vancouver, Canada. Methods Data were derived two open prospective cohorts for period December, 2005 May, 2014. Multivariable generalized estimating equations used odds those injected: POs; heroin; POs heroin. Results total, 1660 (33.7% women) participated study. multivariable analyses, comparison injecting non-opioid drugs, exclusive was not significantly associated with (adjusted ratio [AOR]: 1.17, 95% confidence interval [CI]: 0.74–1.86). The elevated heroin (AOR: 1.72, CI: 1.31–2.27), but greatest injected both 2.46, 1.83–3.30). Discussion Compared non-opioids, exclusively did increase risk overdose; doubled risk. This may reflect consistencies drug potency composition when are used, as well unique characteristics injectors. Our findings call continued scale-up evidence-based prevention interventions opioids, including POs.