Sympathetic activation and inflammatory response in patients with subarachnoid haemorrhage.
作者： Silvana Naredi , Gavin Lambert , Peter Friberg , Stefan Zäll , Elisabeth Edén
DOI: 10.1007/S00134-006-0408-Y
关键词:
摘要: The aim of this study was to evaluate the correlation between sympathetic nervous activation and immune response in patients following subarachnoid haemorrhage (SAH). Clinical a neurosurgical intensive care unit. Fourteen with acute non-traumatic SAH were included. Fifteen healthy, age-matched volunteers served as controls for measurement catecholamine spillover. Blood sampling C3a, C5b-9, IL-6, IL-8 norepinephrine kinetic determination made within 48 h, at 72 h on 7th–10th day after SAH. exhibited a profound increase rate spillover plasma 7–10 days insult, 3–4 times that healthy individuals. levels IL-6 C5b-9 significantly elevated SAH, but level decreased There no relationship magnitude inflammatory markers. Following a pronounced system occurs. lack significant association markers indicates two processes, response, are not quantitatively linked. In spite a persistent high one week
springer.com
sci-hub.se 参考文章(35)
Murray Esler, Graham Jackman, Alex Bobik, Dianne Kelleher, Garry Jennings, Paul Leonard, Helen Skews, Paul Korner, Determination of norepinephrine apparent release rate and clearance in humans Life Sciences. ,vol. 25, pp. 1461- 1470 ,(1979) , 10.1016/0024-3205(79)90371-0
Klaus Fassbender, Siegbert Rossol, Thomas Kammer, Michael Daffertshofer, Steffen Wirth, Martina Dollman, Michael Hennerici, Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease Journal of the Neurological Sciences. ,vol. 122, pp. 135- 139 ,(1994) , 10.1016/0022-510X(94)90289-5
Yuhei Yoshimoto, Yoshihiro Tanaka, Katsumi Hoya, Acute systemic inflammatory response syndrome in subarachnoid hemorrhage Stroke. ,vol. 32, pp. 1989- 1993 ,(2001) , 10.1161/HS0901.095646
David A. Padgett, Ronald Glaser, How stress influences the immune response Trends in Immunology. ,vol. 24, pp. 444- 448 ,(2003) , 10.1016/S1471-4906(03)00173-X
Elenkov Ij, Chrousos Gp, Wilder Rl, Vizi Es, The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System Pharmacological Reviews. ,vol. 52, pp. 595- 638 ,(2000)
FIRDAUS S. DHABHAR, Stress, leukocyte trafficking, and the augmentation of skin immune function. Annals of the New York Academy of Sciences. ,vol. 992, pp. 205- 217 ,(2003) , 10.1111/J.1749-6632.2003.TB03151.X
K Fassbender, Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries Journal of Neurology, Neurosurgery & Psychiatry. ,vol. 70, pp. 534- 537 ,(2001) , 10.1136/JNNP.70.4.534
William E. Hunt, Robert M. Hess, Surgical Risk as Related to Time of Intervention in the Repair of Intracranial Aneurysms Journal of Neurosurgery. ,vol. 28, pp. 14- 20 ,(1968) , 10.3171/JNS.1968.28.1.0014
M. K. Sun, D. J. Reis, Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 266, ,(1994) , 10.1152/AJPREGU.1994.266.1.R245
Graeme Eisenhofer, Sympathetic nerve function--assessment by radioisotope dilution analysis. Clinical Autonomic Research. ,vol. 15, pp. 264- 283 ,(2005) , 10.1007/S10286-005-0292-5