Subcellular control of membrane excitability in the axon.

作者: Scott A Alpizar , In Ha Cho , Michael B Hoppa

DOI: 10.1016/J.CONB.2019.01.020

关键词:

摘要: Ion channels are microscopic pore proteins in the membrane that open and close response to chemical electrical stimuli. This simple concept underlies rapid signaling brain as well several important aspects of neural plasticity. Although soma accounts for less than 1% many neurons by area, it has been major site measuring ion channel function. However, axon is one longest processes found cellular biology hosts a multitude critical functions brain. Not only does initiate rapidly propagate action potentials (APs) across but also forms presynaptic terminals convert these inputs into outputs. Here, we review recent advances physiological role within diverse landscape terminals.

参考文章(82)
Dominique Debanne, Nathalie C. Guérineau, Beat H. Gähwiler, Scott M. Thompson, Action-potential propagation gated by an axonal I A -like K + conductance in hippocampus Nature. ,vol. 389, pp. 286- 289 ,(1997) , 10.1038/38502
Baljit S Khakh, Michael V Sofroniew, None, Diversity of astrocyte functions and phenotypes in neural circuits Nature Neuroscience. ,vol. 18, pp. 942- 952 ,(2015) , 10.1038/NN.4043
Ralf Schneggenburger, Erwin Neher, Intracellular calcium dependence of transmitter release rates at a fast central synapse Nature. ,vol. 406, pp. 889- 893 ,(2000) , 10.1038/35022702
Sean A. Freeman, Anne Desmazières, Desdemona Fricker, Catherine Lubetzki, Nathalie Sol-Foulon, Mechanisms of sodium channel clustering and its influence on axonal impulse conduction Cellular and Molecular Life Sciences. ,vol. 73, pp. 723- 735 ,(2016) , 10.1007/S00018-015-2081-1
Anna N. King, Colleen F. Manning, James S. Trimmer, A unique ion channel clustering domain on the axon initial segment of mammalian neurons. The Journal of Comparative Neurology. ,vol. 522, pp. 2594- 2608 ,(2014) , 10.1002/CNE.23551
Paul D. Dodson, Ian D. Forsythe, Presynaptic K+ channels: electrifying regulators of synaptic terminal excitability Trends in Neurosciences. ,vol. 27, pp. 210- 217 ,(2004) , 10.1016/J.TINS.2004.02.012
M. B. Jackson, A. Konnerth, G. J. Augustine, Action potential broadening and frequency-dependent facilitation of calcium signals in pituitary nerve terminals. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 380- 384 ,(1991) , 10.1073/PNAS.88.2.380
Amandine Duflocq, Fabrice Chareyre, Marco Giovannini, François Couraud, Marc Davenne, Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B BMC Biology. ,vol. 9, pp. 66- 66 ,(2011) , 10.1186/1741-7007-9-66