Mitochondrial junctions with cellular organelles: Ca2+ signalling perspective.

摘要: Cellular organelles form multiple junctional complexes with one another and the emerging research area dealing such structures their functions is undergoing explosive growth. A new journal named "Contact" has been recently established to facilitate development of this field. The current consensus define an organellar junction by maximal distance between participating organelles; gap 30 nm or less considered appropriate for classifying as junctions membrane contact sites. Ideally, should have a functional significance, i.e. transfer calcium, sterols, phospholipids, iron possibly other substances (Carrasco Meyer in Annu Rev Biochem 80:973-1000, 2011; Csordas et al. Trends Cell Biol 28:523-540, 2018; Phillips Voeltz Nat Mol 17:69-82, 2016; Prinz J 205:759-769, 2014). It also important note that not just result random organelle collision but active specific formation, stabilisation disassembly mechanisms. nature these mechanisms role physiology/pathophysiology are main focus In review, we will briefly describe formed cellular then on mitochondria regulating Ca2+ signalling.