Tamoxifen drug resistance related microRNA molecule MiR-200a and application thereof
作者： Zhang Yuan , Chen Suning , Li Mengyang , Zhang Jian
DOI:
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摘要: The invention discloses a tamoxifen drug resistance related microRNA molecule MiR-200a and application thereof, belongs to the field of tumor biotherapy. nucleotide sequence disclosed by is as shown in SEQ ID NO. 1. MiR-200a, novel breast cancer drug-resistance marker, has characteristics low expression ER positive cells high sensitive cells. Therefore, provides new target for designing drugs, subsequently, directly corresponding resistance, are designed developed. biological function an action mechanism promoting cell resistance; therefore, effective way provided reversal improvement clinical chemotherapeutic effect on cancer.
lens.org 参考文章(4)
Penn Muluhngwi, Numan Al-Rayyan, Carolyn M. Klinge, Tissa T. Manavalan, Yun Teng, Lacey M. Litchfield, Reduced Expression of miR-200 Family Members Contributes to Antiestrogen Resistance in LY2 Human Breast Cancer Cells PLoS ONE. ,vol. 8, pp. e62334- ,(2013) , 10.1371/JOURNAL.PONE.0062334
Melissa G. Piper, Clay B. Marsh, Noura Ismail, Mirna expression in human peripheral blood microvesicles and uses thereof ,(2008)
Tissa T. Manavalan, Yun Teng, Savitri N. Appana, Susmita Datta, Theodore S. Kalbfleisch, Yong Li, Carolyn M. Klinge, Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells Cancer Letters. ,vol. 313, pp. 26- 43 ,(2011) , 10.1016/J.CANLET.2011.08.018
Xia Guoqing, Cui Kunyuan, Method and kit for diagnosing liver cancer by use of the ratio of change in serum miRNA quantity ,(2014)