Regulation of the Activity of Eukaryotic Initiation Factors in Stressed Cells
作者： Gert C. Scheper , Roel Van Wijk , Adri A. M. Thomas
DOI: 10.1007/978-3-662-09889-9_2
关键词:
摘要: Exposure of cells to elevated temperatures, also known as heat shock, or exposure other kinds environmental stress, gives rise a general inhibition protein synthesis, on the one hand, and increased synthesis group chaperone proteins, hand (Rhoads Lamphear 1995; Duncan 1996). These proteins shock (HSPs) function mainly in folding refolding denatured newly synthesized therefore counteract toxic effects cell (Wu 1995). The is achieved by reduced initiation translation through inactivation various eukaryotic factors (eIFs; Most studies have implicated eIF2, which involved delivery initiator methionyl tRNA small ribosomal subunit, eIF4E, key component binding several mRNA, main causes levels (e.g., Hershey 1989; et al. Feigenblum Schneider 1996; Scheper 1997; Wang 1998)
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