Use of RNA Domains in the Viral Genome as Innate Immunity Inducers for Antiviral Strategies and Vaccine Improvement

Gretja Schnell, Yueh-Ming Loo, Joseph Marcotrigiano, Michael Gale, Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I PLoS Pathogens. ,vol. 8, pp. e1002839- ,(2012) , 10.1371/JOURNAL.PPAT.1002839

Andrew G. Bowie, Leonie Unterholzner, Viral evasion and subversion of pattern-recognition receptor signalling Nature Reviews Immunology. ,vol. 8, pp. 911- 922 ,(2008) , 10.1038/NRI2436

S. Nejentsev, N. Walker, D. Riches, M. Egholm, J. A. Todd, Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science. ,vol. 324, pp. 387- 389 ,(2009) , 10.1126/SCIENCE.1167728

Robert Besch, Hendrik Poeck, Tobias Hohenauer, Daniela Senft, Georg Häcker, Carola Berking, Veit Hornung, Stefan Endres, Thomas Ruzicka, Simon Rothenfusser, Gunther Hartmann, Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells Journal of Clinical Investigation. ,vol. 119, pp. 2399- 2411 ,(2009) , 10.1172/JCI37155

Bryan R Cullen, None, Viruses and microRNAs: RISCy interactions with serious consequences Genes & Development. ,vol. 25, pp. 1881- 1894 ,(2011) , 10.1101/GAD.17352611

Mitsutoshi Yoneyama, Takashi Fujita, Recognition of viral nucleic acids in innate immunity. Reviews in Medical Virology. ,vol. 20, pp. 4- 22 ,(2010) , 10.1002/RMV.633

Kurt H Edelmann, Sarah Richardson-Burns, Lena Alexopoulou, Kenneth L Tyler, Richard A Flavell, Michael B.A Oldstone, Does Toll-like receptor 3 play a biological role in virus infections? Virology. ,vol. 322, pp. 231- 238 ,(2004) , 10.1016/J.VIROL.2004.01.033

Hiroki Kato, Osamu Takeuchi, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Kosuke Matsui, Satoshi Uematsu, Andreas Jung, Taro Kawai, Ken J. Ishii, Osamu Yamaguchi, Kinya Otsu, Tohru Tsujimura, Chang-Sung Koh, Caetano Reis e Sousa, Yoshiharu Matsuura, Takashi Fujita, Shizuo Akira, Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Nature. ,vol. 441, pp. 101- 105 ,(2006) , 10.1038/NATURE04734

Juan M Pacheco, Mario CS Brum, Mauro P Moraes, William T Golde, Marvin J Grubman, None, Rapid protection of cattle from direct challenge with foot-and-mouth disease virus (FMDV) by a single inoculation with an adenovirus-vectored FMDV subunit vaccine Virology. ,vol. 337, pp. 205- 209 ,(2005) , 10.1016/J.VIROL.2005.04.014

Martin Schlee, Andreas Roth, Veit Hornung, Cristina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, Gunther Hartmann, Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus Immunity. ,vol. 31, pp. 25- 34 ,(2009) , 10.1016/J.IMMUNI.2009.05.008