Construction of a temperature-responsive terpolymer coating with recyclable bactericidal and self-cleaning antimicrobial properties

摘要: Once a biomedical implant is implanted into human body, proteins and bacteria can easily colonize the implant, subsequently, biofilm grow on surface. A protect inhabiting against macrophages neutrophil cell attack from host immune system. The most important issue for artificial antibacterial surfaces accumulation of corpse after they are killed by contact, which promotes further adhesion formation. Therefore, we constructed novel multifunctional bactericidal fouling release surface through combination temperature-responsive N-vinylcaprolactam (VCL), hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC) quaternary ammonium salt (2-(dimethylamino)-ethyl methacrylate (DMAEMA+)). terpolymer coating was prepared surface-initiated reversible addition–fragmentation chain-transfer (RAFT) polymerization characterized using water contact angle measurements, atomic force microscopy spectroscopic ellipsometry. At temperature above lower critical solution (LCST), P(VCL-co-DMAEMA+-co-MPC) in compressed hydrophobic state with low moisture content, displayed efficiency Gram-positive Staphylococcus aureus. could be switched relatively at below LCST, showed self-cleaning properties both bovine serum albumin. functionalized good biocompatibility lens epithelial cells as evaluated morphology studies activity measurements.