Regulation of Protein Mobility via Thermal Membrane Undulations

摘要: The in-plane diffusivelike motion of membrane bound proteins on the surface cells is considered. We suggest, basis theoretical arguments and simulation, that thermally excited undulations lipid bilayer may serve as a mechanism for to hop between adjacent regions cell separated by barriers composed internal cellular structure (e.g., cytoskeleton). specifically investigate mobility band 3 dimer red blood where spectrin cytoskeletal meshwork defines series “corrals” known hinder protein motion. Previous models this system have postulated cytoskeleton must deform allow passage out these corral ignored fluctuations bilayer. Our model provides complementary we posit real in likely result several mechanisms acting parallel.