Allopurinol to Febuxostat: How far have we come?

摘要: For decades allopurinol has been used as a xanthine oxidase inhibitor for treatment of hyperuricemia and gout. Although effective in many patients, some experience sensitivity to the drug. In cases, this may lead hypersensitivity disorder, which if untreated can be fatal. Recently Food Drug Administration approved use febuxostat an alternative therapy Febuxostat is new inhibitor, but not purine based therefore decreases adverse reactions due patient sensitivity. This review comprehensive look at background gout with compared recent clinical studies febuxostat. Each study evaluated summarized, identifying advances that have made well concerns still exist either treatment.