Modelling DNA Repair Pathways: Recent Advances and Future Directions.
作者： Francesco Gentile , Jack A. Tuszynski , Khaled H. Barakat
DOI: 10.2174/1381612822666160420141435
关键词:
摘要: Background: A major class of chemotherapy drugs targets the genome cancer cells. These DNA damaging agents induce damage to DNA helix, resulting in programmed death An overactivated DNA repair mechanism cells can reduce efficacy these drugs, thereby eliminating their therapeutic benefit and developing an acquired resistance otherwise effective drugs. promising approach to enhance therapeutic window damaging is target pathways causing this type resistance. Methods: Computational approaches have been applied successfully study many these DNA mechanisms at different scales focusing on various aspects. The ultimate goal studies has been identify key players design regulators for their activities. This review covers most important recent computational efforts toward this goal. includes modelling mechanisms involved identifying novel pharmacological inhibitors their activities. Results: We focus here mainly the pathways associated with drug agents, concentrating advances the key foreseeing future directions field. Conclusion: hope that short, yet comprehensive can help discovering strategies overcome effects inherent treatments.
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