Searching for a truly "iso-metabolic" gas challenge in physiological MRI.
作者： Shin-Lei Peng , Harshan Ravi , Min Sheng , Binu P Thomas , Hanzhang Lu
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摘要: Hypercapnia challenge (e.g. inhalation of CO2) has been used in calibrated fMRI as well the mapping vascular reactivity cerebrovascular diseases. An important assumption underlying these measurements is that CO2 a pure but does not alter neural activity. However, recent reports have suggested may suppress activity and brain metabolic rate. Therefore, goal this study to propose test gas truly "iso-metabolic," by adding hypoxic component hypercapnic challenge, since hypoxia shown enhance cerebral rate oxygen (CMRO2). Measurement global CMRO2 under various conditions revealed that, while hypercapnia (P = 0.002) individually altered (by -7.6 ± 1.7% 16.7 ± 4.1%, respectively), hypercapnic-hypoxia (5% CO2/13% O2) did change metabolism (CMRO2 change: 1.5 ± 3.9%, P = 0.92). Moreover, blood flow response (in terms % per mmHg change) was even greater than alone (P = 0.007). Findings suggest be useful maneuver physiological MRI it preserves vasodilatory yet metabolism.
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