Water Molecule in Hydrophobic Surroundings: Structure of α-Cyclodextrin-Hexahydrate (C 6 H 10 O 5 ) 6 ·6H 2 O

摘要: α-CYCLODEXTRIN (cyclohexaamylose) is the smallest member of family Schardinger dextrins, a group cyclic D-glucosyl oligosaccharides each consisting six to nine α-(1→4) linked glycopyranoses. These torus shaped molecules have voids approximate diameter 6–9 A and are capable forming inclusion complexes with variety “guest” molecules1,2. In crystalline state, these can exist as either “cage” or “channel” structures, depending on whether cyclodextrins align themselves so that form continuous, extended channels. At least eight different, non-isomorphous modifications α-cyclodextrin various different guest known. Cyclodextrin also in aqueous solution. As it has been proposed3 simultaneously complex formation included solvent (water) released, for an understanding mechanism important determine how many what manner bound interior cyclodextrin ring. The structure we report here · 6H2O (αCDH2O), “empty” complex, cage type.