Involvement of matrix metalloproteinase-2 in medial hypertrophy of pulmonary arterioles in broiler chickens with pulmonary arterial hypertension.
作者： Xun Tan , Juan Chai , Shi-Cheng Bi , Jun-Jun Li , Wen-Wen Li
DOI: 10.1016/J.TVJL.2012.01.017
关键词:
摘要: Medial hypertrophy of pulmonary arterioles during arterial hypertension (PAH) in humans is associated with enhanced proliferation smooth muscle cells (SMCs). Elevated matrix metalloproteinase (MMP)-2 has been found artery SMCs (PA-SMCs) idiopathic PAH, leading to the hypothesis that MMP-2 contributes and migration vascular pathogenesis PAH. Rapidly growing meat-type (broiler) chickens provide a model spontaneous The present study was conducted determine whether involved medial this model. Cultured PA-SMCs from normal birds were used evaluate effect MMPs on cell proliferation. Gelatin zymography showed endothelin (ET)-1-induced concomitant increased pro- active production. Reverse transcription PCR demonstrated upregulation mRNA. However, PA-SMC inhibited by MMP inhibitors doxycycline cis-9-octadecenoyl-N-hydroxylamide. In vivo experiments revealed significant increase expression hypertrophied PAH broiler chickens, which positively correlated wall thickness hypertrophy. may contribute enhancing SMCs.
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