Polymorphisms of pon1 and pon2 genes in hemodialyzed patients
作者： Marija Grdić Rajković , Karmela Barišić , Dubravka Juretić , Tihana Žanić Grubišić , Zlata Flegar-Meštrić
DOI: 10.1016/J.CLINBIOCHEM.2011.05.012
关键词:
摘要: Abstract Objectives Q192R, L55M and -108C>T polymorphisms of pon1 gene affect PON1 paraoxonase activity while S311C polymorphism pon2 might be associated with coronary heart disease. The aims this study were to determine the frequencies L55M, in hemodialyzed patients examine relationship between those patients. Design Methods included 238 control subjects 263 Results was lower Genotype different two compared groups only for polymorphism, group having higher frequency MM genotype. Polymorphisms significant variation both groups. Conclusion Our results suggest that are not by itself causal factors leading
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