摘要: The goals of this study were to determine thesteroid-binding specificity the mouse salivaryandrogen-binding protein (ABP) family and ascertainwhether there might be other proteins in saliva capable binding steroids. optimalconditions for testosterone by salivaryproteins determined using a small-scalechromatography system separate bound from unboundsteroid. Testosterone appeared biphasicbut was directly proportional concentration,with an optimum temperature 37 C second phase.These results used develop steroid-binding protocol steroid ofsalivary separated electrophoresis. ABPfamily progesterone well andHO-progesterone DHT lesser extent but did not bind either cholesterol or estradiol.Steroid structural comparisons suggest that byABP is governed A ring steroid. Anotherprotein member ABP specifically no thatspecifically estradiol observed.
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