New insights into the role of PML in tumour suppression.

摘要: The PML gene is involved in the t(15;17) translocation of acute promyelocytic leukaemia (APL), which generates oncogenic fusion protein (promyelocytic protein)-retinoic acid receptor alpha. localises to a subnuclear structure called nuclear domain (PML-ND), essential structural component. In APL, PML-NDs are disrupted, thus implicating these structures pathogenesis this leukaemia. Unexpectedly, recent studies indicate that and PML-ND play tumour suppressive role several different types human neoplasms addition APL. Because PML's extreme versatility involvement multiple cellular pathways, understanding mechanisms underlying its function, therefore suppression, has been challenging task. review, we attempt critically appraise more advances field propose new avenues investigation.