Cyclic Nucleotide Phosphodiesterases in Health and Disease

摘要: Cyclic Nucleotide Phosphodiesterase Superfamily, J. A. Beavo, M. D. Houslay, and S. H. Francis Isoforms-An Annotated List, G. B. Bolger Section A Specific Families-Regulation, Molecular Biochemical Characteristics Calmodulin-Stimulated Phosphodiesterases, T. Bender PDE2 Structure Functions, E. Martinez 3B: An Important Regulator of Energy Homeostasis, Degerman V. Manganiello Cellular Functions PDE4 Enzymes, Bolger, Conti, Houslay 5: Relating to Structure, Function, Regulation, Francis, R. Zoraghi, Kotera, Ke, P. Bessay, Blount, Corbin Photoreceptor (PDE6): G-Protein-Activated PDE Regulating Visual Excitation in Rod Cone Cells, Cote PDE7, Michaeli cAMP-Phosphodiesterase 8 , Vasta PDE9, Kotera K. Omori PDE10A: Striatum Enriched, Dual-Substrate Phosphodiesterase, C. Strick, Schmidt, F. Menniti PDE11, B Nonmammalian Phosphodiesterases Protozoal L.Wentzinger Seebeck Studies Function Using Fruit Fly Genomics Transgenics, Davies Day C Functional Significance: Gene-Targeted Knockout Strategies Insights into the Physiological from Mice, L. Jin, W. Richter, Conti Regulation cAMP Level by PDE3B-Physiological Implications Balance Insulin Secretion, Z. Zhao Stenson Holst D Compartmentation Signaling Heart Failure, Fibrosis, Metabolism Cardiac Fibroblasts, Epperson Brunton Role A-Kinase Anchoring Proteins Signaling, O. Witczak, Aandahl, Tasken Myocytes, Abi-Gerges, R.V. Castro, Rochais, Vandecasteele, Fischmeister E as Pharmacological Targets Disease Processes PDEs Vascular Health Disease: Endothelial Angiogenesis, Keravis, Silva, Favot, Lugnier Expression Arteries: Controlling Maurice Tilley Smooth Muscle Diseases, Yan, Nagel, Jeon Failure Hypertension, Movsesian Smith Determinants Pulmonary Hypertension: The PDE5, N.J. Pyne, Murray, Tate, M.R. MacLean PDE5 Migraine, Kruuse Phosphodiesterase-4 a Target Mediating Antidepressant Cognitive Effects on Behavior, Zhang O'Donnell Apoptosis, Lerner, Y.Moon, Tiwari F Development Inhibitors Therapeutic Agents Crystal Families Potential for Rational Drug Design, Y. Catalytic Mechanism, Inhibitor Selectivity Ke Wang Bench Bedside: Multiple Actions PDE3 Cilostazol, Kambayashi, Shakur, Liu Reinventing Wheel: Nonselective Chronic Inflammatory Giembycz Medicinal Chemistry Inhibitors, McKenna Muller Index