A "classical" tetrahydroxycalix[4]arene adopting the 1,2-alternate conformation.
作者： Samah Simaan , Silvio E. Biali
DOI: 10.1021/JO035573J
关键词:
摘要: The first example of a “classical” tetrahydroxycalixarene, which adopts the 1,2-alternate conformation both in solution and crystal, is described. Calixarene derivatives with two distal methylene groups substituted trans fashion by phenyl (5a) or mesityl (5b) were synthesized via addition PhMgBr/CuCN MesMgBr/CuCN to bis(spirodiene) derivative 3. Whereas phenyl-substituted calixarene 5a usual “cone” conformation, NMR data X-ray crystallography indicate that more crowded 5b located at isoclinal positions macrocycle.
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