Two dimensional linkage study methods and related inventions

摘要: Versions of the invention are directed to methods (and related techniques) for a new type association based linkage study technique using bi-allelic markers. The markers used in versions studies chosen two-dimensional concept “closeness” terms marker distribution over region having orthogonal dimensions chromosomal location and least common allele frequency. By two characteristics or population frequency this unique way, power systematic nature genetic tests is greatly increased. These techniques increase localize trait causing genes polymorphisms modest effect such as human disease polymorphisms.