Development in Minimal Modelling of IVGTT: The Measurement of Glucose Production

摘要: The minimal modelling approach has been widely applied to assess insulin sensitivity in vivo from intravenous glucose tolerance test (IVGTT) data (Bergman et al., 1985). This technique yields a measurement of the effect that exerts disposition injected glucose, by simultaneously enhancing its tissue utilisation, Rd(t), and inhibiting liver production, Ra(t). Standard IVGTT data, is, plasma concentration time course following bolus injection cold gluccose, do not allow separate estimation contribution each those two factors. use tracer seems therefore best candidate for solving this problem. In previous study (Cobelli 1986) we have developed model analysis when was along with glucose. From estimated on labelled disappearance, were able evaluate, quantita-tive terms, true disposal. possible since allowed segregation confounding production. Therefore, natural pursuance will be assessment To achieve goal, must also included set analysed means IVGTT.