The uremic toxin indoxyl sulfate reflects cardio-renal risk and intestinal-renal relationship
作者： István Kiss
关键词:
摘要: Az uremias szindroma es allapot elsősorban a veseelegtelenseg kovetkezteben felhalmozodo toxinok eredmenyekeppen jon letre. Egyre nagyobb figyelem fordul az eltavolitasanak lehetősegei fele, amely mar nemcsak dializiskezelest jelenti, hanem taplalkozassal kapcsolatos specialis meggondolasokat, illetve toxinokat megkotő, termelődesuket csokkentő lehetősegeket vizsgalja. A kronikus veseelegtelensegben szenvedő betegek vesepotlo kezelesben reszesulők morbiditasaban mortalitasaban kiemelt szerepet jatszanak cardiovascularis kockazatot is novelő toxinok. Ezek koze tartozik cardiorenalis novelő, dializissel nehezen eltavolithato, feherjehez kotott endogen toxin, indolcsoportba tartozo indoxil-szulfat. Mai ismereteink szerint indoxil-szulfat vasculonephrotoxicus anyag, renalis betegsegek progressziojat fokozo toxin. kozott kulonos jelentőseggel bir teny, hogy redox potenciaja reven ...
sci-hub.se 参考文章(48)
Ise M, Niwa T, Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. Journal of Laboratory and Clinical Medicine. ,vol. 124, pp. 96- 104 ,(1994)
Hideki Fujii, Kentaro Nakai, Masafumi Fukagawa, Role of oxidative stress and indoxyl sulfate in progression of cardiovascular disease in chronic kidney disease Therapeutic Apheresis and Dialysis. ,vol. 15, pp. 125- 128 ,(2011) , 10.1111/J.1744-9987.2010.00883.X
Asuman Yavuz, Ciro Tetta, F. Fevzi Ersoy, Vincent D’intini, Ranistha Ratanarat, Massimo De Cal, Monica Bonello, Valeria Bordoni, Gabriella Salvatori, Emilio Andrikos, Gulsen Yakupoglu, Nathan W. Levin, Claudio Ronco, Reviews: Uremic Toxins: A New Focus on an Old Subject Seminars in Dialysis. ,vol. 18, pp. 203- 211 ,(2005) , 10.1111/J.1525-139X.2005.18313.X
Toshimitsu Niwa, Role of indoxyl sulfate in the progression of chronic kidney disease and cardiovascular disease: experimental and clinical effects of oral sorbent AST-120. Therapeutic Apheresis and Dialysis. ,vol. 15, pp. 120- 124 ,(2011) , 10.1111/J.1744-9987.2010.00882.X
Shunsuke Goto, Kunihiko Yoshiya, Tomoyuki Kita, Hideki Fujii, Masafumi Fukagawa, Uremic toxins and oral adsorbents. Therapeutic Apheresis and Dialysis. ,vol. 15, pp. 132- 134 ,(2011) , 10.1111/J.1744-9987.2010.00891.X
Yoshiko Iwasaki, Hideyuki Yamato, Masafumi Fukagawa, Treatment with pravastatin attenuates oxidative stress and protects osteoblast cell viability from indoxyl sulfate. Therapeutic Apheresis and Dialysis. ,vol. 15, pp. 151- 155 ,(2011) , 10.1111/J.1744-9987.2010.00888.X
Yohei Miyamoto, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama, New Insight Into the Redox Properties of Uremic Solute Indoxyl Sulfate as a Pro‐ and Anti‐Oxidant Therapeutic Apheresis and Dialysis. ,vol. 15, pp. 129- 131 ,(2011) , 10.1111/J.1744-9987.2010.00884.X
Amanda C Raff, Timothy W Meyer, Thomas H Hostetter, New insights into uremic toxicity. Current Opinion in Nephrology and Hypertension. ,vol. 17, pp. 560- 565 ,(2008) , 10.1097/MNH.0B013E32830F45B6
Sun-Young Ahn, Sanjay K. Nigam, Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Molecular Pharmacology. ,vol. 76, pp. 481- 490 ,(2009) , 10.1124/MOL.109.056564
Yohei Miyamoto, Yasunori Iwao, Yuka Tasaki, Keizo Sato, Yu Ishima, Hiroshi Watanabe, Daisuke Kadowaki, Toru Maruyama, Masaki Otagiri, The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions. FEBS Letters. ,vol. 584, pp. 2816- 2820 ,(2010) , 10.1016/J.FEBSLET.2010.04.046