Detection of bronchial preneoplastic lesions and early lung cancer with fluorescence bronchoscopy: A study about its ambulatory feasibility under local anaesthesis

摘要: Abstract Background: Autofluorescence bronchoscopy (AB) enhances the bronchoscopist’s ability to diagnose bronchial preneoplastic lesions and early cancer. We undertook a study assess its feasibility performance under local anaesthesia on real ambulatory mode. Methods: Thirty-four consecutive patients at very high risk for lung cancer were prospectively studied by AB anaesthesia, without any sedation. Lidocaine doses, time, oxygen saturation, peak expiratory flow (PEF) number of cough episodes measured. Continuous assessment respiratory sensation was obtained with visual analog scale. A total 172 biopsies performed in abnormal normal areas. Results: The procedure long-lasting (mean±SD: 26.6±6.0 min), required doses (660±107 mg) significant side effect, associated decreases O 2 saturation from 98.5±1.4 96.1±2.5% PEF 380±96 310±78 l/min. However, counts moderate majority reported no discomfort. 62 hyperplasia, metaplasia, dysplasia carcinoma situ (CIS) detected relative sensitivity AB+white-light (WLB) versus WLB alone 3.75 intraepithelial corresponding or worse. Conclusions: AB, that increases our recognize cancer, can be systemic sedation