Obligatory Role for the Immediate Early Gene NARP in Critical Period Plasticity

摘要: Summary The immediate early gene neuronal activity-regulated pentraxin (NARP) is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) binding protein that specifically enriched at excitatory synapses onto fast-spiking parvalbumin-positive interneurons (FS [PV] INs). Here, we show transgenic deletion of NARP decreases the number synaptic inputs FS (PV) INs and reduces net drive INs. Accordingly, visual cortex −/− mice hyperexcitable unable to express ocular dominance plasticity, although many aspects function are unimpaired. Importantly, strength inhibitory contacts from principle neurons in normal mice, enhancement this output recovers expression experience-dependent plasticity. Thus recruitment inhibition plays a central role enabling critical period for