Nervous Control of Urinary Bladder in Cats: III. Effects of autonomic blocking agents in the intact animal

摘要: Edvardsen, P. Nervous control of urinary bladder in cats. III. Effects autonomic blocking agents the intact animal. Acta physiol. scand. 1968. 72. 183–193. Bladder motility anesthetized or decerehrated cats was recorded under isometric conditions before and after administration graded doses various with peripheral ganglionic effects on nervous system. Direct indirect cystometry employed when collecting expulsion phase, respectively, were studied. Atropine, which blocks at cholinergic receptor sites, made micturition contraction inefficient as ability to sustain initial abolished. Hexamethonium, transmission, impaired spontaneous well: by also preventing, pressure rise from occurring. The drug blocked sympathetic ganglia smaller than those parasympathetic ones. propranolol dibenzyline, block adrenergic inhibitory excitatory receptors suggest that both these are present bladder. former increased tone, latter had an atropine-like effect influence reflex. Finally, guanethidine, neuro-muscular junction, a facilitatory reflex addition its presynaptic effect. These results support previous hypotheses inhibition absence activity during determinant threshold.