Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5
作者： Marta Alenquer , Sandra Tenreiro , Isabel Sá-Correia
DOI: 10.1111/J.1567-1364.2006.00095.X
关键词:
摘要: The expression of the transcription regulator Pdr1p and its target genes PDR5 TPO1 is required for Saccharomyces cerevisiae adaptation resistance to artesunate, a promising antimalarial drug, also active against tumour cells viruses. encode plasma membrane multidrug transporters ATP-binding cassette major facilitator superfamilies, respectively. transcriptional activation (10-fold) (13-fold) was registered after 30 min exposure unadapted yeast population acute artesunate-induced stress, being significantly reduced in absence abolished Pdr3p. Maximum mRNA levels were rapidly basal values following while high maintained during drug-stressed exponential growth.
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