Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 2—External Validity and Correlates

摘要: Effort-based decision making has strong conceptual links to the motivational disturbances that define a key subdomain of negative symptoms. However, extent which effort-based decision-making performance relates symptoms, and other clinical functionally important variables yet be systematically investigated. In 94 clinically stable outpatients with schizophrenia, we examined external validity 5 paradigms, including Effort Expenditure for Rewards, Balloon Effort, Grip Strength Deck Choice Perceptual tasks. These tasks covered 3 types effort: physical, cognitive, perceptual. Correlations between effort related 6 classes were examined, including: (1) (2) rated motivation community role functioning, (3) self-reported traits, (4) neurocognition, (5) psychiatric symptoms clinical/demographic characteristics, (6) subjective valuation monetary rewards. paradigms showed small medium relationships ratings motivation, pattern more consistent some measures than others. They also relations neurocognitive but generally unrelated antipsychotic medications, side effects, money. There relatively interrelationships among measures. conjunction findings from companion psychometric article, all warrant further consideration development, 2 show strongest potential trial use at this juncture.