Both GLUT-1 and GLUT-14 are Independent Prognostic Factors in Gastric Adenocarcinoma

摘要: The role of glucose transporter 14 (GLUT-14/SLC2A14) in tumor biology is entirely unknown, and the significance hypoxia inducible factor 1-alpha (HIF1-α) for gastric adenocarcinoma controversial. impact GLUT-1/SLC2A1 has never been confirmed a Caucasian cohort. Between 1996 2007, 124 patients underwent gastrectomy adenocarcinoma. Tumor sections were incubated with GLUT-1, GLUT-14, HIF1-α antibodies. Expression was analyzed correlations histopathology, marker coexpression, patient survival by uni- multivariate analyses. Expressions detectable 50, 77.4, 27.1 %, respectively. GLUT-1 associated pT-category (p = 0.019), pN-category tubular (WHO, p = 0.008), intestinal (Lauren classification; p = 0.002) histologic subtypes. GLUT-14 correlated pT category (p = 0.043), whereas did not show any correlation histopathology or survival. median period 14 months (95 % confidence interval [CI] 9.2–18.8 months) GLUT-1-positive 55 months CI 25.8–84.2; p = 0.01) GLUT-1-negative patients. An inferior prognosis also seen GLUT-14-positive cases compared GLUT-14-negative (p = 0.004). Thus, worst both GLUT-1- expression followed single-positive then double-negative In analysis including International Union Against Cancer (UICC) stages, R category, Lauren classification, surgery alone versus neoadjuvant/perioperative chemotherapy, as covariates, (p = 0.011) (p = 0.025) kept their prognostic independence. The study findings suggest that detection high value. It gives additional information to UICC stages identifies prognosis. If prospective studies, these markers need be considered future classification systems.