EGFR Polymorphism of the Kinase Domain in Japanese Lung Cancer

摘要: Background Mutations of the epidermal growth factor receptor (EGFR) gene at kinase domain have been reported in non-small-cell lung cancer (NSCLC), and some common somatic mutations EGFR examined for their ability to predict sensitivity gefitinib or erlotinib. However, exon 20 resistance therapy. Materials methods We investigated and/or polymorphism statuses 303 surgically treated non-small cell (NSCLC) cases. One hundred ninety-four adenocarcinoma cases were included. The presence absence domains was analyzed by direct sequences. also status 23 NSCLC patients who had undergone surgery followed treatment with National Hospital Organization, Kinki-chuo Chest Medical Center. Results found 75 patients. During sequencing tyrosine tumors, 86 (G2607A) identified 20. G2067A significantly higher nonadenocarcinomas (37.4%) than (25.3%, P = 0.0415). did not correlate gender, smoking (never smoker versus smoker), mutations. In 46 total patients, there a tendency toward better prognosis wild type (GG) AG + AA Japanese cancers seemed be less frequent Caucasian cancers. Conclusions EGFR-tyrosine might associated clinicopathological background