Antiretroviral Therapy for HIV-2 Infected Patients

摘要: Abstract Objectives : To evaluate clinical and RNA load response to antiretroviral therapy amongst patients infected with HIV-2 study the development of drug resistance. Methods Seven seropositive were monitored examination, CD4 cell count viral load. Viruses from four subjects genotyped in vitro recovery virus by co-cultivation PBMCs HVS T-cells was attempted. isolated two assayed for phenotypic antiviral The main outcome measures relationship between disease stage, load, count, subtype course infection effect combination on progression, Results median time follow-up 3 years (range 0–8 years). Three had AIDS, one symptomatic disease. Of genotyped, three B A. Viraemia detectable only at counts less than 300 × 10 6 /ml. Two high loads failed respond although their treatment may not have been optimal. One developed genotype this patient's reverse transcriptase is being analysed. Conclusions In contrast HIV-1, levels often undetectable despite advanced low counts. However, clearly capable causing depletion resulting principles highly active seem apply suboptimal lead timing initiation, monitoring measurement resistance remain unresolved issues conclusions cannot be extrapolated HIV-1.