Omental transposition to bypass the blood brain barrier for delivery of chemotherapeutic agents to malignant brain tumours: preclinical investigation

摘要: Primary neoplasms of the central nervous system (CNS) occur with an approximate incidence 4.5 cases per 100 000 population annually, and approximately 25% to 35% these tumours are malignant (1,2). Despite aggressive new approaches in treating lesions, mortality rate has not changed dramatically over past ten 15 years. This is extremely disappointing when one considers that patients succumb this disease due primarily effects local recurrence subsequent mass effect (1). Malignant gliomas rarely metastasize outside CNS (3), and, indeed, infrequently result death cerebrospinal fluid dissemination and/or multicentricity. Hochberg (4) demonstrated 90% 95% recurrences within two centimetres contrast enhancing margin as depicted by computed tomography (CT) scans.