C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

摘要: Background Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement markers has been proposed as method improve prediction risk these events. Methods We conducted prospective, nested case–control study among 28,263 apparently healthy postmenopausal women over mean follow-up period three years assess events associated with base-line levels inflammation. The included high-sensitivity C-reactive protein (hs-CRP), serum amyloid A, interleukin-6, and soluble intercellular adhesion molecule type 1 (slCAM-1). also studied homocysteine several lipid lipoprotein measurements. Cardiovascular were defined death from coronary heart disease, nonfatal myocardial infarction or stroke, need for coronay-revascularization procedures. Results Of 12 measured, hs-CRP was strongest univariate predictor events; relative highest compared lowest quartile this marker 4.4 (95 percent confidence interval, 2.2 8.9). Other significantly A (relative quartile, 3.0), slCAM-1 (2.6), interleukin-6 (2.2), (2.0), total cholesterol (2.4), low-density (LDL) apolipoprotein B-100 (3.4), high-density (HDL) (0.3), ratio HDL (3.4). Prediction models that incorporated addition lipids better at predicting than based on alone (P<0.001). significant predictors even subgroup LDL below 130 mg per deciliter (3.4 mmol liter), target primary prevention established by National Cholesterol Education Program. In multivariate analyses, only plasma independently predicted 1.5; 95 1.1 2.1) risk, 1.4; 1.9). Conclusions screening may provide an improved identifying