Frequency of monosomy X in women with primary biliary cirrhosis
作者： Pietro Invernizzi , Monica Miozzo , Pier Maria Battezzati , Ilaria Bianchi , Francesca R Grati
DOI: 10.1016/S0140-6736(04)15541-4
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摘要: Summary The mechanisms that cause the female predominance of primary biliary cirrhosis (PBC) are uncertain, but X chromosome includes genes involved in immunological tolerance. We assessed rate monosomy peripheral white blood cells from 100 women with PBC, 50 chronic hepatitis C, and healthy controls, by fluorescence in-situ hybridisation. Frequency increased age all groups, was significantly higher PBC than controls (p
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