Glucose tolerance and plasma insulin in newborn infants of normal and diabetic mothers.

摘要: Extract: Infants born to diabetic mothers remove glucose more rapidly from plasma than do infants of normal mothers. The tolerance newborns in the first hour after intravenous injection is poorer child or adult. have higher levels insulin-like activity a few minutes an load normals. rate removal during second loading, however, enhanced mothers; this correlates with later peak immunologically reactive insulin baby. Glucose and were determined under identical conditions 14 mothers, who had received insulin, 6 not one mother glucosuria pregnancy whose baby looked like infant mother. was expressed as ‘total index’ (Kt), percentage disappearing minute. Insulin by method Hales RANDLE [9]. Kt women (0.44 2.31, mean 1.16) differed little that non-insulin-treated (1.51 1.93, 1.31). both groups significantly insulin-treated whom range 0.83 5.78, 3.30. In hour, appeared fall, while rise. These observations on correlate changes groups. Although individual differences existed within groups, for normals rose 49, μU/ml before glucose-loading 139 at two after. level then fell, but climbed again reach value 229 hour. contrast, group 34 prior loading 208 loading. There was, if any peak. presence antiinsulin antibodies makes impossible accurate measurement babies been treated insulin; case, treatment so brief no antibody formed. This showed high ephemeral response load. found persistent had, absence antibody, highest observed. Speculation: hours life, released load, size speed suggest it simply reflects which infant's pancreas has submitted utero specific relation status readily removed result release yet opposing mechanisms increasing are relatively ineffective age, although neonatal liver contains glycogen. Glycogen can be administering glucagon, suggesting appropriate metabolic pathways functional. When delayed because intrauterine stimulation small, hormone nonetheless effective lowering glucose. reported homeostasis exist newborn, hormonal controlling these inappropriately invoked.